2009
Suárez-Castillo Oscar R., Meléndez-Rodríguez Myriam, Morales-García Ana L., Cano-Escudero Indira C., Contreras-Martínez Yaneth M. A., Morales-Ríos Martha S., Joseph-Nathan Pedro . Synthesis of indolylindolines mediated by t-BuNH2 Heterocycles 78, 1463-1476 (2009). ISSN 0385-5414. DOI: 10.3987/COM-08-11627
Abstract
An improved synthesis of N1-carbomethoxylated indolylindolines 2 from 5-substituted indoles 1, by replacing the previously employed strong acids or toxic metals with t-BuNH2/MeOCOCl in CH2Cl2/H2O, is described. The substituent effect of electron donor or acceptor groups was examined, revealing that electron-deficient indoles are less reactive to dimerization than electron-rich indoles, with 5-cyano and 5-nitroindoles leading to no reaction. A dynamic process caused by the restricted rotation of the N-CO2Me bond of 2 was evidenced by 1H NMR measurements.
Trapping enols of esters and lactones with diazomethane
Synthesis of Indolylindolines Mediated by tert-BuNH2
Unimolecular rearrangements of ketene-O,O-acetals and fragmentations occurring in the gas phase
Regioselective Synthesis of 3-Indolyl(alkoxy)acetates
One-potsynthesis of conformationallyrestrictedspirooxindoles
Stereochemical assignment of naturally occurring 2,3-epoxy-2-methylbutanoate esters
Synthesis of Bromoindole Alkaloids from Laurencia brongniartii