Producción Científica Profesorado

Sequential Injection Spectrophotometric Determination of Diclofenac in Urine and Pharmaceutical Formulations



Páez Hernández, María Elena

2008

Rodriguez, J.A., Islas, G., Paez-Hernandez, M.E., E. Barrado. Sequential injection spectrophotometric determination of diclofenac in urine and pharmaceutical formulations. J. Flow Injection Anal., 25:1 (2008) 3943. Preprinted


Abstract


This paper reports a sequential injection spectrophotometric method for determining the concentration of diclofenac (DCF) in urine samples and pharmaceutical formulations. The method is based on the reaction of DCF with potassium permanganate in an alkaline medium. The influence on the analytical signal of the reactor length, the permanganate volume, the sample volume and the flow rate was investigated using a Taguchi parameter design. Under optimal conditions, the linear range of the calibration curve varied from 10.0 to 100.0 mg l-1, with a detection limit of 5.0 mg l-1. A sampling rate of 15 determinations h-1 was achieved; the relative standard deviation of analytical repeatability was less than 3.0% in all cases. The method was validated by comparing the results obtained against those provided by RP-HPLC; no significant differences were seen (p<0.05)



Producto de Investigación




Artículos relacionados

Magnetic solid phase extraction based on phenyl silica adsorbent for the determination of tetracycli...

Determination of primary amino acids in wines by high performance liquid magneto-chromatography

Synthesis and crystal structures of cis-palladium(II) and cis-platinum(II) complexes containing dipy...

Design and Construction of Solid State Ag/AgCl Reference Electrodes Through Electrochemical Depositi...

Potentiometric behavior of graphite-epoxy electrochemical transducers towards anions, cations and pH...

Development of a Polypyrrole Selective Membrane For The Potentiometric Quantification of Saccharinat...

High-performance liquid magneto-chromatography

Determination of tetracyclines in milk samples by magnetic solid phase extraction flow injection ana...

Characterization of Main Anthocyanins Extracted from Pericarp Blue Corn by MALDI-ToF MS

Potentiometric quantification of saccharin by using a selective membrane formed by pyrrole electropo...