Producción Científica Profesorado

Sequential Injection Spectrophotometric Determination of Diclofenac in Urine and Pharmaceutical Formulations

Páez Hernández, María Elena


Rodriguez, J.A., Islas, G., Paez-Hernandez, M.E., E. Barrado. Sequential injection spectrophotometric determination of diclofenac in urine and pharmaceutical formulations. J. Flow Injection Anal., 25:1 (2008) 3943. Preprinted


This paper reports a sequential injection spectrophotometric method for determining the concentration of diclofenac (DCF) in urine samples and pharmaceutical formulations. The method is based on the reaction of DCF with potassium permanganate in an alkaline medium. The influence on the analytical signal of the reactor length, the permanganate volume, the sample volume and the flow rate was investigated using a Taguchi parameter design. Under optimal conditions, the linear range of the calibration curve varied from 10.0 to 100.0 mg l-1, with a detection limit of 5.0 mg l-1. A sampling rate of 15 determinations h-1 was achieved; the relative standard deviation of analytical repeatability was less than 3.0% in all cases. The method was validated by comparing the results obtained against those provided by RP-HPLC; no significant differences were seen (p<0.05)

Producto de Investigación

Artículos relacionados

Renewable stationary phase liquid magnetochromatography: determining aspartame and its hydrolysis pr...

Facilitated transport of Hg(II) through novel activated composite membranes

Development of a Chloride Ion-Selective Solid State Sensor Based on Doped Polypyrrole-Graphite-Epoxy...

Characterization of Main Anthocyanins Extracted from Pericarp Blue Corn by MALDI-ToF MS

Synthesis, characterization, and crystal structures of n-alkyldiorganodithiophosphates RS2P(OC6H4)2

Development of a Polypyrrole Selective Membrane For The Potentiometric Quantification of Saccharinat...

Magnetic solids in analytical chemistry: A review

Potentiometric quantification of saccharin by using a selective membrane formed by pyrrole electropo...

Synthesis and crystal structures of cis-palladium(II) and cis-platinum(II) complexes containing dipy...

Characterization of Main Anthocyanins Extracted from Pericarp Blue Corn by MALDI-ToF MS