Synthesis of Acetamido(indol-3-yl)propanol Derivatives

A series of acetamido(indol-3-yl)propanol derivatives (5-7) has been synthesized using a variety of reductive reactions performed on the corresponding O-methyl oximes of an indol-3-yl ester and of several indol-3-yl alcohol derivatives. The O-methyl oximes were prepared in good yields by acylation of the corresponding zinc salt of indole, followed by O-methyl oximation.