Producción Científica Profesorado

Voltammetric Quantification of Diclofenac Using a Modified CPE Enriched With TiO2 Nanoparticles and MWCNT



Alvarez Romero, Giaan Arturo

2021

Miriam Franco-Guzmán, Luis Humberto Mendoza-Huizar, Gabriela Roa-Morales, Carlos Andrés Galán-Vidal and Giaan Arturo Álvarez-Romero, Voltammetric Quantification of Diclofenac Using a Modified CPE Enriched With TiO2 Nanoparticles and MWCNT. J. Electrochem. Soc., 2021, 168, 037502


Abstract


This work describes the development of a voltammetric methodology based on a carbon paste electrode enriched with multiwalled carbon nanotubes and TiO2 nanoparticles, for the electrochemical quantification of diclofenac. All stages of the methodology were optimized by a Box-Behnken experimental design. The electrochemical behavior of diclofenac was studied by cyclic voltammetry. Results showed that the oxidation of diclofenac is favored by the presence of both MWCNT and TiO2 nanostructures since a considerable increase in the anodic peak current is observed when compared to a that obtained with a bare carbon paste electrode. Under the optimal values found and with the appropriate statistical analysis, a LOD of 0.33 ?M, a LOQ of 1.11 ?M, a linear concentration range from 1.1 × 10?6 to 5 × 10?3 M (R2 = 0.9958), and a sensitivity of 0.487 ?A.?M?1 were found. The electrode's response was precise as the reproducibility resulted to be 4.39% (%RSD). Finally, a study of possible interferences was performed, along with the quantification of diclofenac in pharmaceutical samples by the proposed voltammetric methodology. The voltammetric method was validated by comparing the results with those obtained with the UV?vis spectrophotometric method.






Artículos relacionados

Synthesis, characterization, and crystal structures of n-alkyldiorganodithiophosphates RS2P(OC6H4)2

Development of a Chloride Ion-Selective Solid State Sensor Based on Doped Polypyrrole-Graphite-Epoxy...

Magnetic solid phase extraction based on phenyl silica adsorbent for the determination of tetracycli...

Development of a Chloride Ion-Selective Solid State Sensor Based on Doped Polypyrrole-Graphite-Epoxy...

Construction and Evaluation of a Gold Tubular Electrode for Flow Analysis: Application to Speciation...

Potentiometric quantification of saccharin by using a selective membrane formed by pyrrole electropo...

Determination of oxytetracycline in milk samples by polymer inclusion membrane separation coupled to...

Estudio de las Interacciones Ácido Húmico-Metales Pesados y Determinación de sus Constantes de Estab...

Design and Construction of Solid State Ag/AgCl Reference Electrodes Through Electrochemical Depositi...

Synthesis and crystal structures of cis-palladium(II) and cis-platinum(II) complexes containing dipy...