Producción Científica Profesorado

Voltammetric Quantification of Diclofenac Using a Modified CPE Enriched With TiO2 Nanoparticles and MWCNT



Galan Vidal, Carlos Andres

2021

Miriam Franco-Guzmán, Luis Humberto Mendoza-Huizar, Gabriela Roa-Morales, Carlos Andrés Galán-Vidal and Giaan Arturo Álvarez-Romero, Voltammetric Quantification of Diclofenac Using a Modified CPE Enriched With TiO2 Nanoparticles and MWCNT. J. Electrochem. Soc., 2021, 168, 037502


Abstract


This work describes the development of a voltammetric methodology based on a carbon paste electrode enriched with multiwalled carbon nanotubes and TiO2 nanoparticles, for the electrochemical quantification of diclofenac. All stages of the methodology were optimized by a Box-Behnken experimental design. The electrochemical behavior of diclofenac was studied by cyclic voltammetry. Results showed that the oxidation of diclofenac is favored by the presence of both MWCNT and TiO2 nanostructures since a considerable increase in the anodic peak current is observed when compared to a that obtained with a bare carbon paste electrode. Under the optimal values found and with the appropriate statistical analysis, a LOD of 0.33 ?M, a LOQ of 1.11 ?M, a linear concentration range from 1.1 × 10?6 to 5 × 10?3 M (R2 = 0.9958), and a sensitivity of 0.487 ?A.?M?1 were found. The electrode's response was precise as the reproducibility resulted to be 4.39% (%RSD). Finally, a study of possible interferences was performed, along with the quantification of diclofenac in pharmaceutical samples by the proposed voltammetric methodology. The voltammetric method was validated by comparing the results with those obtained with the UV?vis spectrophotometric method.






Artículos relacionados

A theoretical quantum study on the distribution of electrophilic and nucleophilic active sites on Ag...

Influence of the Cation Nature of the Sulphate Salt on the Electrochemical Synthesis of Sulfate-Dope...

The role of temperature in copper electrocrystallization in ammoniachloride solutions

Theoretical and Experimental Study of Cobalt Nucleation and Growth onto Gold Substrate with Differen...

Predicting the Phase Diagram of a Liquid Crystal Using the Convex Peg Model and the Semiempirical PM...

Cobalt electrodeposition onto highly oriented pyrolytic graphite (HOPG) electrode from ammonium sulf...

Cobalt electrodeposition on polycrystalline palladium. Influence of temperature on kinetic parameter...

Cobalt Electrodeposition Process from Electrolytic Baths based on CoSO4 and (NH4)2SO4. Influence of ...

Nucleation and growth of cobalt onto different substrates: Part I. Underpotential deposition onto a ...

Revisión de variables de diseño y condiciones de operación en la electrocoagulación