Producción Científica Profesorado

New insights on diclofenac electrochemistry using graphite as working electrode



Páez Hernández, María Elena

2017

G.Y. Aguilar-Lira, G.A. Álvarez-Romero, A. Zamora-Suárez, M. Palomar-Pardavé, A. Rojas-Hernández, J.A. Rodríguez-Ávila, M.E. Páez-Hernández. New insights on diclofenac electrochemistry using graphite as working electrode. Journal of Electroanalytical Chemistry 794 (2017) 182-188. doi:10.1016/j.jelechem.2017.03.050


Abstract


This paper reports new investigation on the electrochemical behavior of diclofenac using a bare graphite electrode. The electrochemical oxidation of diclofenac was studied using cyclic voltammetry (CV), an anodic peak was found at 0.557 V as reported earlier by other authors, reversing the cycle results in a new cathodic peak at 0.272 V, which is proposed to be related with the reduction of 2-(2hydroxyprop-2-enyl) acetic acid. During the second cycle a new cathodic peak is observed at 0.333 V, associated to the oxidation of 2-(2hydroxyprop-2-enyl) acetic acid to 1-hydroxy-2-(hydroxyphenyl) ethanalate. Both electrochemical processes resulted to be adsorption-controlled, statistical fit of theoretical information with the experimental voltammograms, one electron transference is demonstrated which supports the proposed mechanism. From an analytical point of view, it was demonstrated that direct quantification of diclofenac using the anodic oxidation peak results less favorable when compared with an indirect quantification using the 2-(2hydroxyprop-2-enyl) acetic acid oxidation peak. The modified Simplex method was used to optimize differential pulse voltammetry parameters to achieve an exact and precise quantification of diclofenac in standard and real samples obtaining very competitive results compared with other more sophisticated working electrodes.



Producto de Investigación




Artículos relacionados

Construction and Evaluation of a Gold Tubular Electrode for Flow Analysis: Application to Speciation...

Presence and antimicrobial resistance of Escherichia coli isolated from foodstuffs in Hidalgo State ...

Synthesis and crystal structures of cis-palladium(II) and cis-platinum(II) complexes containing dipy...

Kinetics of Polypyrrole Films Doped with Sulphate Ions Electrodeposited Over Graphite - Epoxy Resin ...

Estudio de las Interacciones Ácido Húmico-Metales Pesados y Determinación de sus Constantes de Estab...

Influence of the Cation Nature of the Sulphate Salt on the Electrochemical Synthesis of Sulfate-Dope...

Characterization of Main Anthocyanins Extracted from Pericarp Blue Corn by MALDI-ToF MS

Mercury Ions Removal from Aqueous Solution Using an Activated Composite Membrane

Development of a novel composite sensor based on doped pyrrole selective to nitrate ions

Multicommutated Anodic Stripping Voltammetry at Tubular Bismuth Film Electrode for Lead Determinatio...