Producción Científica Profesorado

Copper(II) complexes supported by click generated mixed NN, NO, and NS 1,2,3-triazole based ligands and their catalytic activity in azide?alkyne cycloaddition



Suárez Castillo, Oscar Rodolfo

2014

Daniel Mendoza-Espinosa, Alejandro Álvarez-Hernández, Guillermo Enrique Negrón-Silva, Oscar R. Suárez-Castillo, Deyanira Ángeles-Beltrán and Rosa Santillán. Copper(II) complexes supported by click generated mixed NN, NO, and NS 1,2,3-triazole based ligands and their catalytic activity in azide?alkyne cycloaddition. Dalton Trans. 2014, 43, 7069-7077.


Abstract


The preparation and characterization of four new copper(II) complexes supported by click generated mixed NN, NO, and NS 1,2,3-triazoles are reported. The four complexes display a 1 : 2 copper/ligand ratio and give monomeric units in the solid state. Crystal structures demonstrate that depending on the flexibility of the ligand NX (X = O, N, S) pendant arm, the coordination environment around the metal center can feature square planar or octahedral geometries. All four complexes are catalytically active at room temperature in a copper-catalyzed alkyne?azide cycloaddition (CuAAC) reaction using sodium ascorbate as a reducing agent and water?ethanol as a solvent mixture. Complex 8 supported by the NS ligand displayed the best catalytic performance of the series allowing for the easy and high yielding preparation of a variety of mono-, bis- and tris-1,2,3-triazoles under low catalyst loadings.



Producto de Investigación




Artículos relacionados

Conformationalstudies of N-carbomethoxy-2-alkoxyindolenines by dynamic NMR, crystallography, and mol...

13C NMR and crystallographic evidence of push-pull effects in furoindolic ?-enamino esters

Synthesis of 6-bromo-2-arylindoles using 2-iodobenzoic acid as precursor

Firsttotalsyntheses of dihydroflustramine C and flustramine E, alkaloids from the marine bryozoan Fl...

Aromatic Bromination versus Oxidation of Indolylmalonates by Bromine

Role of lipid peroxidation in biliary obstruction in the rat

Stereochemical assignment of naturally occurring 2,3-epoxy-2-methylbutanoate esters

Cleavage of alkoxycarbonyl protecting groups from carbamates by t-BuNH2

Synthesis of Bromoindole Alkaloids from Laurencia brongniartii

Configuration, stereodynamics and crystal structure of 3-substituted-2-oxofuro[2,3-b]indoles