Producción Científica Profesorado

Recent Advances in the Enantioselective Synthesis of b-Amino Acids

Lopez Ruíz, Heraclio


E. Juaristi y Heaclio López-Ruiz Recent Advances in the Enantioselective Synthesis of b-Amino Acids. Current Medicinal Chemistry, 6, 983-1004 (1999). Preprinted


The introductory section of this review presents some of the currently most compelling b-amino acid targets, according to their structural types: a- and b-aryl substituted, olefinic and alkynyl, a,a- and a,b-disubstituted, cyclic and conformationally restricted, fluorine-containing, and phosphonic analogous b-amino acids. The main section highlights some of the very new (1996-1998), promising methodology for the enantioselective synthesis of b-amino acids, with especial emphasis on catalytic and enzymatic processes, as well as methods based on chiral pool, self-regeneration of stereogenic centers, diastereoselective nucleophilic additions to prochiral double bonds, and enantioselective reactions in the presence of chiral additives.

Artículos relacionados

Et3, and efficient Mediator for Xanthate Transfer Based Radical Processes.

Study of the reactivity of squarylferrocenes. Addition of amines and aminoesters


3-Benzoyl-2-isopropyl-4-alkyloxazolidin-5-ones as Efficient and Inexpensive Sources of Enantiopure ?...

Further insight into three center hydrogen bonding. Participation in tautomeric equilibria of hetero...

Stereoselective addition of allylmagnesium chloride to the CN bond of [4.3.0] boron heterobicycles

The Structural Chemistry of N-Monolithium Borazines

Addition reaction of benzylbenzylidenenamine to lithium enolates of1,3-dioxolan-4-one: synthesis of ...

Ylidaddukte der Penteltrichloride

Synthesis of nitrogen-, oxygen- and sulphur-containing tripodal ligands with a trimethylbenzene core...