Producción Científica Profesorado

Recent advances in the synthesis, design and selection of cysteine protease inhibitors



Alvarez Hernandez, Alejandro

2002

Alejandro Alvarez Hernandez and William R. Roush. Recent advances in the synthesis, design and selection of cysteine protease inhibitors. Current Opinion in Chemical Biology, 2002, 6, 459-465. ISSN: 1367-5931. Elsevier. Londres.


Abstract


Inhibition of cysteine proteases is emerging as an important strategy for the treatment of a variety of human diseases. Intense efforts involving structure-based inhibitor design have been directed toward several cysteine proteases, including cathepsin K, calpain, human rhinovirus 3C protease and several parasitic cysteine protease targets. Other successful recent efforts have involved combinatorial synthesis and screening for identification of new inhibitor templates.






Artículos relacionados

Preparation of Seven- and Eight-Membered Boron Heterocycles from Different Salen Ligands and Arylbor...

Et3, and efficient Mediator for Xanthate Transfer Based Radical Processes.

Bis(acetylsalicylato-j2O,O00)diaquacadmium(II)

Diastereoselective Synthesis of Spiro-?-lactams via Staudinger Reaction

Furocoumarins of three species of the genus Dorstenia

Synthesis and Study of Isomeric Benzo[1,4]oxazines and Benzothiazolines by NMR Spectroscopy and X-Ra...

Phenylboronic acid catalyzed-cyanide promoted, one-pot synthesis of 2-(2-hydroxyphenyl)benzoxazole d...

Synthesis, crystal structures, and quadratic nonlinear optical properties in a series of pushpull bo...

Further insight into three center hydrogen bonding. Participation in tautomeric equilibria of hetero...

Addition reaction of benzylbenzylidenenamine to lithium enolates of 1,3-dioxolan-4-one: synthesis of...