Mendoza-Huizar, L. H., Ramirez Tagle, R., Salgado-Moran, G., Lashgari , A., Ghamami, S., Cardona Villada, W., & Gerli Candia, L. (2021). Synthesis, Chemical Identification, Drug Release and Docking Studies of the Amlodipine?Chitosan Nanobiopolymer Composite. Journal of the Chilean Chemical Society, 66(1), 5063-5066.
A new amlodipine-chitosan nanocomposite was built using amlodipine nanoparticles as primary scaffolds by spontaneous emulsification, and its complete elucidation was performed by using several spectrometric techniques. Our results indicate that the amlodipine-chitosan nanocomposite has better solubility than amlodipine at pH 7.4 with a nearly all the drug substance dissolved (97%) by the final time-point measured. The docking study support the existence of intermolecular interactions are established between amlodipine and chitosan.