2014
Mendoza-Espinosa, D. Negrón-Silva, G. Lomas-Romero, L.; Gutiérrez-Carrillo, A.; Santillán, R. Facile One-pot Synthesis of 1,2,3-triazoles Featuring Oxygen, Nitrogen and Sulfur Pendant Arms. Synthetic Commun., 2014, 44, 807-817.
Abstract
A practical and efficient one-pot synthesis of novel 1,2,3-triazoles featuring nitrogen, oxygen, and sulfur functionalized pendant arms has been developed. The click reaction of mono-propargyl derivatives supported by aniline, thiophenol, and benzyl alcohol, with sodium azide and p-substituted benzyl halogenides, renders a series of N-substituted-1,2,3-triazoles in good yields under mild reaction conditions. The catalyst system was based in Cu(OAc)2 H2O, sodium L-ascorbate, and 1,10-phenanthroline monohydrate, and all reactions were performed in a mixture H2O?ethanol (4:1 v/v). Additionally, the preparation of bis-1,2,3-triazoles supported by di-propargylated aniline was carried out, demonstrating the versatility of the present methodology.
Conformational studies on indole alkaloids from Flustra foliacea by NMR and molecular modeling
Synthesis of Indolylindolines Mediated by tert-BuNH2
13C NMR and crystallographic evidence of push-pull effects in furoindolic ?-enamino esters
Aromatic Bromination versus Oxidation of Indolylmalonates by Bromine
Regioselective Synthesis of 3-Indolyl(alkoxy)acetates
Cleavage of alkoxycarbonyl protecting groups from carbamates by t-BuNH2