Producción Científica Profesorado

Facile One-pot Synthesis of 1,2,3-triazoles Featuring Oxygen, Nitrogen and Sulfur Pendant Arms. Synthetic Commun., 2014, 44, 807-817.



Mendoza Espinosa, Daniel

2014

Mendoza-Espinosa, D. Negrón-Silva, G. Lomas-Romero, L.; Gutiérrez-Carrillo, A.; Santillán, R. Facile One-pot Synthesis of 1,2,3-triazoles Featuring Oxygen, Nitrogen and Sulfur Pendant Arms. Synthetic Commun., 2014, 44, 807-817.


Abstract


A practical and efficient one-pot synthesis of novel 1,2,3-triazoles featuring nitrogen, oxygen, and sulfur functionalized pendant arms has been developed. The click reaction of mono-propargyl derivatives supported by aniline, thiophenol, and benzyl alcohol, with sodium azide and p-substituted benzyl halogenides, renders a series of N-substituted-1,2,3-triazoles in good yields under mild reaction conditions. The catalyst system was based in Cu(OAc)2 H2O, sodium L-ascorbate, and 1,10-phenanthroline monohydrate, and all reactions were performed in a mixture H2O?ethanol (4:1 v/v). Additionally, the preparation of bis-1,2,3-triazoles supported by di-propargylated aniline was carried out, demonstrating the versatility of the present methodology.



Producto de Investigación




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