Producción Científica Profesorado

A Persistent(Amino)(Ferrocenyl)carbene.



Mendoza Espinosa, Daniel

2011

deHope, A.; Mendoza-Espinosa, D.; Donnadieu, B.; Bertrand, G. A Persistent(Amino)(Ferrocenyl)carbene. New J. Chem. 2011, 35, 2037-2042


Abstract


Deprotonation of N,N-diisopropyl-C-ferrocenylaldiminium triflate 2 cleanly leads to the corresponding 1,2-diamino-1,2-diferrocenylethene 3, the dimer of the desired (amino)(ferrocenyl)carbene. Fulvene 6, obtained by addition of the lithium salt of tetramethylcyclopentadiene to methoxyformamidinium methylsulfate 5, reacts with dicarbonylcyclopentadienylbromoiron(II), and with a mixture of FeCl2 and Cp* lithium salt, affording the corresponding tetramethylferrocenylaldiminium salt 7, and nonamethylferrocenylaldiminium salt 8, respectively. Although the deprotonation of 7 gives a complex mixture of products, the treatment of 8 at ?78 C with sodium hexamethyldisilazide allowed for the isolation of the corresponding (amino)(ferrocenyl)carbene 9 as a yellow powder. However, even in the solid state, it is stable for less than 48 h at ?20 C. In addition to NMR spectroscopy, evidence for the carbene nature of 9 was found by a trapping experiment with sulfur that leads to the corresponding adduct 10, which was characterized by a single crystal X-ray diffraction study.



Producto de Investigación




Artículos relacionados

First Total Synthesis of ()-Flustraminol B

Synthesis of Bromoindole Alkaloids from Laurencia brongniartii

Aromatic Bromination versus Oxidation of Indolylmalonates by Bromine

Absolute configuration determination of 2-(2-oxo-3-indolyl)acetamide derivatives

13C NMR and crystallographic evidence of push-pull effects in furoindolic ?-enamino esters

Conformational studies on indole alkaloids from Flustra foliacea by NMR and molecular modeling

Total Syntheses of Five Indole Alkaloids from the Marine Bryozoan Flustra foliacea

Unimolecular rearrangements of ketene-O,O-acetals and fragmentations occurring in the gas phase

Synthesis of 6-bromo-2-arylindoles using 2-iodobenzoic acid as precursor

Synthesis of ?4:?2-Exocyclic-Diene Iridium(I) Complexes Derived from 1,3-Oxazolidin-2-ones and Their...