Producción Científica Profesorado

DEVELOPMENT OF A SECOND TYPE ELECTRODE BASED ON THE SILVER/SILVER IBUPROFENATE PAIR FOR IBUPROFEN QUANTIFICATION IN PHARMACEUTICAL SAMPLES



Páez Hernández, María Elena

2017

Selene I. Rivera-Hernández, Giaan A. Álvarez-Romero, Silvia Corona-Avendaño, M. Elena Páez-Hernández, CarlosA. Galán-Vidal, Mario Romero-Romo, María Teresa Ramírez-Silva, Quim. Nova, 2017, 40 (1) 68-73.


Abstract


Ibuprofen is a widely used pharmaceutical because of its therapeutic properties; it is considered a safe medicament, thus it does notrequire medical prescription to be sold. However, in order to ensure consumer?s health it is indispensable that the pharmaceuticalindustry relies on analytic methods for its quantification. Potentiometry has proven to be a successful technique using second typeelectrodes, which in agreement with Nernst?s equation can detect anions activity. On consideration of this, this research work presentsthe development of a second type electrode based on the silver/silver ibuprofenate pair. This involved modifying a pure silver wireusing a sodium ibuprofenate solution, to obtain the redox pair. The following analytic parameters were obtained with the aid of themodified electrode: a sensitivity of -0.049 V decade [ibuprofenate]?1, 8 mol L-1 for the detection limit and a quantification limit of1.2 mol L-1. The repeatability value in terms of the relative standard deviation was 5.9%. After performing an interferences analysisusing some ions and excipients, it was corroborated that there were none, thus allowing appropriate quantification on a real sample.



Producto de Investigación




Artículos relacionados

Mercury Ions Removal from Aqueous Solution Using an Activated Composite Membrane

Potentiometric behavior of graphite-epoxy electrochemical transducers towards anions, cations and pH...

Determination of tetracyclines in milk samples by magnetic solid phase extraction flow injection ana...

Simultaneous determination of tetracyclines in poultry muscle by capillary zone electrophoresis

Development of a novel nitrate-selective composite sensor based on doped polypyrrole

Presence and antimicrobial resistance of Escherichia coli isolated from foodstuffs in Hidalgo State ...

Chemical studies of anthocyanins: A review

Prevalence and Antimicrobial Resistance Patterns of Salmonella from Different Raw Foods in Mexico

Potentiometric quantification of saccharin by using a selective membrane formed by pyrrole electropo...

cis-Palladium(II) complexes of derivatives of di-(2-pyridyl)methane: Study of the influence of the b...