Producción Científica Profesorado

Copper(II) complexes supported by click generated mixed NN, NO, and NS 1,2,3-triazole based ligands and their catalytic activity in azide?alkyne cycloaddition



Alvarez Hernandez, Alejandro

2014

Daniel Mendoza-Espinosa, Alejandro Álvarez-Hernández, Guillermo Enrique Negrón-Silva, Oscar R. Suárez-Castillo, Deyanira Ángeles-Beltrán and Rosa Santillán. Copper(II) complexes supported by click generated mixed NN, NO, and NS 1,2,3-triazole based ligands and their catalytic activity in azide?alkyne cycloaddition. Dalton Trans. 2014, 43, 7069-7077.


Abstract


The preparation and characterization of four new copper(II) complexes supported by click generated mixed NN, NO, and NS 1,2,3-triazoles are reported. The four complexes display a 1 : 2 copper/ligand ratio and give monomeric units in the solid state. Crystal structures demonstrate that depending on the flexibility of the ligand NX (X = O, N, S) pendant arm, the coordination environment around the metal center can feature square planar or octahedral geometries. All four complexes are catalytically active at room temperature in a copper-catalyzed alkyne?azide cycloaddition (CuAAC) reaction using sodium ascorbate as a reducing agent and water?ethanol as a solvent mixture. Complex 8 supported by the NS ligand displayed the best catalytic performance of the series allowing for the easy and high yielding preparation of a variety of mono-, bis- and tris-1,2,3-triazoles under low catalyst loadings.



Producto de Investigación




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