Producción Científica Profesorado

Stereochemical assignment of naturally occurring 2,3-epoxy-2-methylbutanoate esters



Villagómez Ibarra, José Roberto

2002

Stereochemical Assignment of Naturally Occurring 2,3-Epoxi-2- methylbutanoate Esters, J. Martín Torres-Valencia, Guadalupe I. León, J. Roberto Villagómez-Ibarra, Oscar R. Suarez.Castillo, Carlos M. Cerda-García-Rojas and Pedro Joseph-Nathan. Phytochemical analysis, 13, 329-332 (2002).


Abstract


A method to determine the absolute configuration of 2,3-epoxy-2-methylbutanoate ester residues in natural products is presented, based on (i) the reduction of the ester function to yield a 2-methyl-1,2-butanediol, (ii) esterification of the obtained primary alcohol with either (R)-(+)- or (S)-(?)-Mosher's acid to afford the corresponding Mosher's ester, and (iii) 1H-NMR spectral comparison of the final product with that of the Mosher's esters prepared from 2-methyl-1,2-butanediols of known stereochemistry. Copyright 2002 John Wiley & Sons, Ltd.






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