Producción Científica Profesorado

Detection of Cytotoxic Activity of Lectin on Human Colon Adenocarcinoma (Sw480) and Epithelial Cervical Carcinoma (C33-A)



Villagómez Ibarra, José Roberto

2011

Detection of Cytotoxic Activity of Lectin on Human Colon Adenocarcinoma (Sw480) and Epithelial Cervical Carcinoma (C33-A), Carmen Valadez-Vega,*, Gerardo Alvarez-Manilla, Leticia Riverón-Negrete, Alejandro García-Carrancá, José A. Morales-González, Clara Zuñiga-Pérez, Eduardo Madrigal-Santillán, Jaime Esquivel-Soto, Cesar Esquivel-Chirino, Roberto Villagómez-Ibarra, Mirandeli Bautista and Ángel Morales-González, Molecules, (2011), vol 16, 2107-2118. ISSN 1420-3049. Editorial MDPI open Access. País Switzerland. Publicado 2 de marzo del 2011.


Abstract


Lectins comprise a heterogeneous class of proteins that recognize the carbohydrate moieties of glycoconjugates with high specificity. Numerous studies have shown that lectins are capable of recognizing specific carbohydrate moieties displayed by malignant cells or tissues. The present work was performed to investigate the effects of tepary bean (Phaseolus acutifolius) lectins on proliferation, colony formation, and alteration of DNA synthesis of human malignant cells. Tepary bean lectin showed dose dependent effects on the inhibition of viability as well as on colony formation in two human malignant cells lines (C33-A, Sw480); By contrast, tepary bean lectin only showed significant effects on DNA synthesis on Sw480 cells. Our results provide evidence of the anti- proliferative and cytotoxic effects of the tepary bean lectins on C33-A and Sw480 cells lines.



Producto de Investigación




Artículos relacionados

Estudio químico de cinco plantas mexicanas de uso común en la medicina tradicional

Lead, Cadmium and Cobalt (Pb, Cd, and Co) Leaching of Glass-Clay Containers by pH Effect of Food

Antioxidant constituents from Geranium bellum Rose

Purification, Biochemical Characterization, and Bioactive Properties of a Lectin Purified from the S...

Effect of the particle size on the activity of MoOxCy catalysts for the isomerization of heptane

Detection of Cytotoxic Activity of Lectin on Human Colon Adenocarcinoma (Sw480) and Epithelial Cervi...