Diastereoselective Synthesis of Spiro-?-lactams via Staudinger Reaction
Rojas Lima, Susana
2007
Susana Rojas-Lima, Lidia Santillan-Sid, Heraclio López-Ruiz, y Alejandro Alvarez-Hernandez. Diastereoselective synthesis of spiro-beta-lactams via staudinger reaction. Heterocycles 71, 531-542 (2007). DOI: 10.3987/COM-06-10942
Abstract
In this work, eleven new spiro-?-lactams have been prepared using the Staudinger reaction of isomaleimides (1a-d) and carboxylic acids (chloroacetic acid, (-)-menthoxyacetic acid (7) and an oxazolidinone derived acid (10)) in the presence of triphosgene under mild condition. All reactions have been shown to be stereoselective. The new stereogenic centers were assigned by X-ray diffraction.
Artículos relacionados
Study of the reactivity of squarylferrocenes. Addition of amines and aminoesters
Diastereomeric C-glycosyloxanthrones from picramnia antidesma
A practical access to acyl radicals from acyl hydrazides
Synthesis of new homochiral 2,3-dialkylpiperazines derived from (R)-(?)-phenylglycinol