Producción Científica Profesorado

Diastereoselective Synthesis of Spiro-?-lactams via Staudinger Reaction



Rojas Lima, Susana

2007

Susana Rojas-Lima, Lidia Santillan-Sid, Heraclio López-Ruiz, y Alejandro Alvarez-Hernandez. Diastereoselective synthesis of spiro-beta-lactams via staudinger reaction. Heterocycles 71, 531-542 (2007). DOI: 10.3987/COM-06-10942


Abstract


In this work, eleven new spiro-?-lactams have been prepared using the Staudinger reaction of isomaleimides (1a-d) and carboxylic acids (chloroacetic acid, (-)-menthoxyacetic acid (7) and an oxazolidinone derived acid (10)) in the presence of triphosgene under mild condition. All reactions have been shown to be stereoselective. The new stereogenic centers were assigned by X-ray diffraction.



Producto de Investigación




Artículos relacionados

An efficient potassium cyanide-promoted synthesis of 2-arylbenzoxazoles from [4.3.0]boron heterobicy...

ChemInform Abstract: Facile Preparation of [4.4]Metacyclophane- and [5.5]Paracyclophane-Type Macrocy...

Synthesis of nitrogen-, oxygen- and sulphur-containing tripodal ligands with a trimethylbenzene core...

Enantioselective synthesis of ?-amino acids. Part 11: Diastereoselective alkylation of chiral deriva...

A practical access to acyl radicals from acyl hydrazides

Stereoselective addition of allylmagnesium chloride to the CN bond of [4.3.0] boron heterobicycles

Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of Pla...

Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.

Structural studies of spiroarsoranes derived from 2-aminophenols

Furocoumarins of three species of the genus Dorstenia