Producción Científica Profesorado

Sequential Injection Spectrophotometric Determination of Diclofenac in Urine and Pharmaceutical Formulations



Rodríguez Ávila, José Antonio

2008

Rodriguez, J.A., Islas, G., Paez-Hernandez, M.E., Barrado, E. Sequential injection spectrophotometric determination of diclofenac sodium in urine and pharmaceutical formulation, Journal Flow Injection Analysis, 2008, Vol. 25, Num. 1, p. 39-43, ISSN 0911-775X


Abstract


This paper reports a sequential injection spectrophotometric method for determining the concentration of diclofenac (DCF) in urine samples and pharmaceutical formulations. The method is based on the reaction of DCF with potassium permanganate in an alkaline medium. The influence on the analytical signal of the reactor length, the permanganate volume, the sample volume and the flow rate was investigated using a Taguchi parameter design. Under optimal conditions, the linear range of the calibration curve varied from 10.0 to 100.0 mg l-1, with a detection limit of 5.0 mg l-1. A sampling rate of 15 determinations h-1 was achieved; the relative standard deviation of analytical repeatability was less than 3.0% in all cases. The method was validated by comparing the results obtained against those provided by RP-HPLC; no significant differences were seen (p<0.05)



Producto de Investigación




Artículos relacionados

Development of a novel composite sensor based on doped pyrrole selective to nitrate ions

Determination of tetracyclines in milk samples by magnetic solid phase extraction flow injection ana...

Development of a Polypyrrole Selective Membrane For The Potentiometric Quantification of Saccharinat...

Prevalence and Antimicrobial Resistance Patterns of Salmonella from Different Raw Foods in Mexico

High-performance liquid magneto-chromatography

Determination of non-steroidal anti-inflammatory drugs in wastewaters by magnetic matrix solid phase...

Synthesis and crystal structures of cis-palladium(II) and cis-platinum(II) complexes containing dipy...

Sequential Injection Spectrophotometric Determination of Diclofenac in Urine and Pharmaceutical Form...

Determination of glucose by flow injection analysis with amperometric detection at Fe(III)-(tris(3,5...

Construction and Evaluation of a Gold Tubular Electrode for Flow Analysis: Application to Speciation...