Producción Científica Profesorado

Sequential Injection Spectrophotometric Determination of Diclofenac in Urine and Pharmaceutical Formulations



Páez Hernández, María Elena

2008

Rodriguez, J.A., Islas, G., Paez-Hernandez, M.E., E. Barrado. Sequential injection spectrophotometric determination of diclofenac in urine and pharmaceutical formulations. J. Flow Injection Anal., 25:1 (2008) 3943. Preprinted


Abstract


This paper reports a sequential injection spectrophotometric method for determining the concentration of diclofenac (DCF) in urine samples and pharmaceutical formulations. The method is based on the reaction of DCF with potassium permanganate in an alkaline medium. The influence on the analytical signal of the reactor length, the permanganate volume, the sample volume and the flow rate was investigated using a Taguchi parameter design. Under optimal conditions, the linear range of the calibration curve varied from 10.0 to 100.0 mg l-1, with a detection limit of 5.0 mg l-1. A sampling rate of 15 determinations h-1 was achieved; the relative standard deviation of analytical repeatability was less than 3.0% in all cases. The method was validated by comparing the results obtained against those provided by RP-HPLC; no significant differences were seen (p<0.05)



Producto de Investigación




Artículos relacionados

Determination of non-steroidal anti-inflammatory drugs in wastewaters by magnetic matrix solid phase...

Characterization of Main Anthocyanins Extracted from Pericarp Blue Corn by MALDI-ToF MS

Sequential Injection Spectrophotometric Determination of Diclofenac in Urine and Pharmaceutical Form...

Validation of a tubular bismuth film amperometric detector: Determination of diclofenac sodium by mu...

Chemical studies of anthocyanins: A review

Determination of tetracyclines in milk samples by magnetic solid phase extraction flow injection ana...

Simultaneous determination of tetracyclines in poultry muscle by capillary zone electrophoresis

Construction and Evaluation of a Gold Tubular Electrode for Flow Analysis: Application to Speciation...

Silver and Silver Chloride Electrodeposits, an Alternative in the Construction of Ag/AgCl Solid Elec...

Nucleation and Growth Kinetics of Electrodeposited Sulfate-Doped Polypyrrole: Determination of the D...