Producción Científica Profesorado

Recent advances in the synthesis, design and selection of cysteine protease inhibitors



Alvarez Hernandez, Alejandro

2002

Alejandro Alvarez Hernandez and William R. Roush. Recent advances in the synthesis, design and selection of cysteine protease inhibitors. Current Opinion in Chemical Biology, 2002, 6, 459-465. ISSN: 1367-5931. Elsevier. Londres.


Abstract


Inhibition of cysteine proteases is emerging as an important strategy for the treatment of a variety of human diseases. Intense efforts involving structure-based inhibitor design have been directed toward several cysteine proteases, including cathepsin K, calpain, human rhinovirus 3C protease and several parasitic cysteine protease targets. Other successful recent efforts have involved combinatorial synthesis and screening for identification of new inhibitor templates.






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