Producción Científica Profesorado

Effect of Sodium Fluoride Ingestion on Malondialdehyde Concentration and the Activity of Antioxidant Enzymes in Rat Erythrocytes



Morales González, Jose Antonio

2010

Morales-González JA, Gutiérrez-Salinas J, García-Ortiz L, Del Carmen Chima-Galán M, Madrigal-Santillán E, Esquivel-Soto J, Esquivel-Chirino C, González-Rubio MG. Effect of sodium fluoride ingestion on malondialdehyde concentration and the activity of antioxidant enzymes in rat erythrocytes. Int J Mol Sci. 2010; 11:2443-52. ISSN: 1422-0067


Abstract


Fluoride intoxication has been shown to produce diverse deleterious metabolic alterations within the cell. To determine the effects of sodium fluoride (NaF) treatment on malondialdehyde (MDA) levels and on the activity of antioxidant enzymes in rat erythrocytes, Male Wistar rats were treated with 50 ppm of NaF or were untreated as controls. Erythrocytes were obtained from rats sacrificed weekly for up to eight weeks and the concentration of MDA in erythrocyte membrane was determined. In addition, the activity of the enzymes superoxide, dismutase, catalase, and glutathione peroxidase were determined. Treatment with NaF produces an increase in the concentration of malondialdehyde in the erythrocyte membrane only after the eight weeks of treatment. On the other hand, antioxidant enzyme activity was observed to increase after the fourth weekOPEN ACCESSInt. J. Mol. Sci. 2010, 11 2444of NaF treatment. In conclusion, intake of NaF produces



Producto de Investigación UAEH




Artículos relacionados

Diabetes. Tratamiento nutricional

Effect of Sodium Fluoride Ingestion on Malondialdehyde Concentration and the Activity of Antioxidant...

Lead, Cadmium and Cobalt (Pb, Cd, and Co) Leaching of Glass-Clay Containers by pH Effect of Food

In vivo extracellular matrix protein expression by human periodontal ligament after stimulation with...

Antigenotoxic Studies of Different Substances to Reduce the DNA Damage Induced by Aflatoxin B1 and O...

Diabetes. Tratamiento nutricional

Protective effect of some vitamins against the toxic action of ethanol on liver regeneration induced...

Antigenotoxic Effect of Chamomilla recutita (L.) Rauschert Essential Oil in Mouse Spermatogonial Cel...

Investigation on the Protective Effect of ?-Mannan against the DNA Damage Induced by Aflatoxin B1 in...

Hepatoprotective effects of glycine and vitamin E, during the early phase of liver regeneration in t...