Producción Científica Profesorado

Antihyperalgesia Induced by Heliopsis longipes Extract



Cariño Cortés, Raquel

2009

Ortiz MI, Cariño-Cortés R, Pérez-Hernández N, Ponce-Monter H, Fernández-Martínez E, Castañeda-Hernández G, Acosta-Madrid II, Cilia-López VG Antihyperalgesia Induced by Heliopsis longipes Extract. Proc West Pharmacol Soc. 2009;52:75-77. ISSN: 0083-8969.


Abstract


Heliopsis longipes is an herbaceous plant found in Mexico. Heliopsis longipes is traditionally used for its analgesic and anesthetic properties. Plant extracts may represent a therapeutic advantage for the clinical treatment of pain. Therefore, the main objective of this study was to determine the possible antihyperalgesic effect produced by the Heliopsis longipes ethanolic extract (HLEE) in the Hargreaves model of thermal hyperalgesia in the mouse. HLEE was administrated systemically to mice and the antihyperalgesic effect was evaluated using the thermal hyperalgesia test. Oral Administration of HLEE produced a dose-dependent antihyperalgesic effect. Previously, it was reported that Heliopsis longipes extract was able to release GABA in mice temporal cortex slices. Therefore, it is likely that the antihyperalgesic effect observed in our study could result from GABA liberation and its inhibition of excessive excitation of nociceptive circuits in the thalamus and cortex evoked by tissue injury. Our results suggest that HLEE may represent a therapeutic advantage for the clinical treatment of inflammatory pain.



Producto de Investigación UAEH




Artículos relacionados

Hepatoprotective effects of glycine and vitamin E, during the early phase of liver regeneration in t...

Antigenotoxic Studies of Different Substances to Reduce the DNA damage Induced by Aflatoxin B1 and ...

Detection of Cytotoxic Activity of Lectin on Human Colon Adenocarcinoma (Sw480) and Epithelial Cervi...

Antigenotoxic Effect of Chamomilla recutita (L.) Rauschert Essential Oil in Mouse Spermatogonial Cel...

Inflammation, Oxidative Stress, and Obesity

Purification, Biochemical Characterization, and Bioactive Properties of a Lectin Purified from the S...

Fluorides and dental fluorosis in students from Tula de Allende Hidalgo, Mexico

Exposure to Sodium Fluoride Produces Signs of Apoptosis in Rat Leukocytes

Protective effect of some vitamins against the toxic action of ethanol on liver regeneration induced...

Diabetes. Tratamiento nutricional