2017
Claudia I. Bautista-Hernández, Nayely Trejo-Carbaja, , Erick A. Zúñiga-Estrada, Alberto Aristeo-Dominguez, , Myriam Meléndez-Rodríguez, Oscar R. Suárez-Castillo, Maricruz Sánchez-Zavala, Julián Cruz-Borbolla, Martha S. Morales-Ríos, Pedro Joseph-Nathan, Tetrahedron: Asymmetry 28 (2017) 762?782http://dx.doi.org/10.1016/j.tetasy.2017.04.011
Abstract
A convenient approach for the absolute configuration assignment of secondary alcohols in the (8R,1?R,2?S,5?R)-15,25, (8S,1?R,2?S,5?R)-15,25, (8R,1?R)-21?24, and (8S,1?R)-21?24 ester series, and of primary amines in the (8R,1?R)-32?37 and (8S,1?R)-32?37 amide series, by means of 1H NMR and VCD spectroscopy, using 2-cyano-2-indolylpropanoic acid as a chiral derivatizing agent is presented. DFT calculations were carried out to demonstrate the anisotropic effect of the indole skeleton on the chiral alcohol or the amine fragment. Vibrational circular dichroism (VCD) measurements of the above series indicated a VCD bisignated couplet resulting from the interaction of the ester carbonyl group and the single bondCN group. The absolute configuration assignments were further tested by X-ray diffraction analysis.
Synthesis of Indolylindolines Mediated by tert-BuNH2
Mechanisticstudies of the photochemicalrearrangement of 1-oxolongipin-2-ene derivatives
Photochemical rearrangements of highly functionalized longipinene derivatives
DFT and NMR parameterized conformation of valeranone
Synthesis of Bromoindole Alkaloids from Laurencia brongniartii
Transesterifications mediated by t-BuNH2