Phenylboronic Acid/CuSO4 as an Efficient Catalyst for the Synthesis of 1,4-Disubstituted-1,2,3-Triazoles from Terminal Acetylenes and Alkyl Azides
Rojas Lima, Susana
2015
José Emilio de la Cerda-Pedro, Susana Rojas-Lima, Rosa Santillan and Heraclio López-Ruiz*, Phenylboronic Acid/CuSO4 as an Efficient Catalyst for the Synthesis of 1,4-Disubstituted-1,2,3-Triazoles from Terminal Acetylenes and Alkyl Azides, J. Mex. Chem. Soc. 2015, 59(2), 130-136
Abstract
The synthesis of 1,4-disubstituted-1,2,3-triazoles from alkylazides and terminal alkynes at room temperature and under microwaveheating was attained using Cu(I), generated in-situ fromcopper(II) sulfate and phenylboronic acid, as catalyst. Twelve newtriazoles were obtained in moderate to good yields (53-98%), and theproducts were obtained by crystallization from the mixture reactionwithout further purification
Artículos relacionados
Diastereoselective Synthesis of Spiro-?-lactams via Staudinger Reaction
Stereoselective addition of allylmagnesium chloride to the CN bond of [4.3.0] boron heterobicycles
A flexible access to highly functionalised boronates
Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.