Producción Científica Profesorado

Phenylboronic Acid/CuSO4 as an Efficient Catalyst for the Synthesis of 1,4-Disubstituted-1,2,3-Triazoles from Terminal Acetylenes and Alkyl Azides



Rojas Lima, Susana

2015

José Emilio de la Cerda-Pedro, Susana Rojas-Lima, Rosa Santillan and Heraclio López-Ruiz*, Phenylboronic Acid/CuSO4 as an Efficient Catalyst for the Synthesis of 1,4-Disubstituted-1,2,3-Triazoles from Terminal Acetylenes and Alkyl Azides, J. Mex. Chem. Soc. 2015, 59(2), 130-136


Abstract


The synthesis of 1,4-disubstituted-1,2,3-triazoles from alkylazides and terminal alkynes at room temperature and under microwaveheating was attained using Cu(I), generated in-situ fromcopper(II) sulfate and phenylboronic acid, as catalyst. Twelve newtriazoles were obtained in moderate to good yields (53-98%), and theproducts were obtained by crystallization from the mixture reactionwithout further purification



Producto de Investigación




Artículos relacionados

Furocoumarins of three species of the genus Dorstenia

Preparation of N-aryl-substituted spiro-?-lactams via Staudinger cycloaddition

Highly diastereoselective alkylation, acylation and aldol condensation of cis- and trans-(N-acyloyl)...

Facile synthesis of 1,3,6-oxadiazepines from 2,2?-(1,2-ethanediyldiimino)bisphenols

An efficient potassium cyanide-promoted synthesis of 2-arylbenzoxazoles from [4.3.0]boron heterobicy...

Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.

Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of Pla...

Addition reaction of benzylbenzylidenenamine to lithium enolates of 1,3-dioxolan-4-one: synthesis of...

3-Benzoyl-2-isopropyl-4-alkyloxazolidin-5-ones as Efficient and Inexpensive Sources of Enantiopure ?...

Diastereoselective Synthesis of Spiro-?-lactams via Staudinger Reaction