Producción Científica Profesorado

Effect of diclofenac with B vitamins for the treatment of acute pain originated by lower-limb fracture and surgery.



Fernández Martínez, Tomas Eduardo

2012

Ponce-Monter, H., Ortiz, M.I., Garza-Hernández, A.F., Monroy-Maya, R., Soto-Ríos, M., Carrillo-Alarcón, L., Reyes-García, G., Fernández-Martínez, E. (2012). Effect of diclofenac with B vitamins for the treatment of acute pain originated by lower-limb fracture and surgery. Pain Research and Treatment, article ID 104782.


Abstract


The aim of this study was to compare the efficacy of diclofenac, for the treatment of acute pain originated by lower-limb fracture and surgery, with that of diclofenac plus B vitamins. This was a single-center, prospective, randomized and double-blinded clinical trial. Patients with lower-limb closed fractures rated their pain on a 10-cm visual analog scale (VAS). Patients were then randomized to receive diclofenac or diclofenac plus B vitamins (thiamine, pyridoxine and cyanocobalamin) intramuscularly twice daily. Patient evaluations of pain intensity were recorded throughout two periods: twenty-four hours pre-surgery and twenty-four hours post-surgically. One hundred twenty-two patients completed the study. The subjects? assessments of limb pain on the VAS showed a significant reduction from baseline values regardless of the treatment group. Diclofenac plus B vitamins combination was more effective to reduce the pain than diclofenac alone. The results showed that the addition of B vitamins to diclofenac increased its analgesic effect.



Producto de Investigación UAEH




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