2012
Morales-Rios, MS; Rivera-Becerril, E; Lopez-Camacho, PY ; Perez-Rojas, NA ; Suarez-Castillo, OR, Preparation of O-Methyl Substituted 2-Oxofuro- and 2-Oxopyrrolidinoindolines by Reductive Lactonization of Oxindol-3-ylacetic Acids, NATURAL PRODUCT COMMUNICATIONS. Año: 2012 Volume: 7 Issue: 11 Pages: 1445-1451.ISSN: 1934-578X
Abstract
A practical procedure for the preparation of O-methyl substituted 3a,8-dialkyl-2-oxofuroindolines is described. Reductive lactonization of the corresponding oxindol-3-ylacetic acids provides a route for the formation of this class of compounds. Further transformation of 2-oxofuroindolines into 2-oxopyrrolidinoindolines, and then to pyrrolidinoindolines demonstrates their versatility as key intermediates in natural products synthesis. The results of single-crystal X-ray crystallographic analyses are given for five of the studied compounds.
First Total Synthesis of ()-Flustraminol B
Stereochemical assignment of naturally occurring 2,3-epoxy-2-methylbutanoate esters
Total Syntheses of Five Indole Alkaloids from the Marine Bryozoan Flustra foliacea
Absolute configuration determination of 2-(2-oxo-3-indolyl)acetamide derivatives
Role of lipid peroxidation in biliary obstruction in the rat
Synthesis of 6-bromo-2-arylindoles using 2-iodobenzoic acid as precursor
Aromatic Bromination versus Oxidation of Indolylmalonates by Bromine