Acid-base equilibrium studies of 2-(aminomethyl)benzimidazolein aqueous solution
Tapia Benavides, Antonio Rafael
2002
Araceli Sierra-Zenteno, Carlos A. Galán-Vidal*, Rafael Tapia-Benavides, Acid-Base Equilibrium Studies of 2-(aminomethyl)benzimidazole in Aqueous Solution, Revista de la Sociedad Química de México, 46, 125-130 (2002). ISSN (Versión impresa): 1870-249X. ISSN (Versión en línea): 1665-9686
Abstract
The acid-base equilibrium constats of the 2-(amino-methyl)benzimidazole 2AMBZ in aqueous solutions have been determined at 25 C by means of nuclear magnetic resonance spectroscopy (13C NMR), and corroborated by potentiometric and spectrophotometric techniques. pKa values were otained from experimental data using the computer programs HypNMR, SUPERQUAD and SQUAD respectively, finding pKa1 = 3.103 +- 0.079, pKa2 = 7.624 +- 0.063 and pKa3 = 12.540 +- 0.038 by NMR ant variable ionic strength. Likewise, it was possible determine the deprotonation mechanism of 2AMBZ.
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