Producción Científica Profesorado

Diastereoselective Synthesis of Spiro-?-lactams via Staudinger Reactio



Lopez Ruíz, Heraclio

2007

Susana Rojas-Lima, Lidia Santillan-Sid, Heraclio López-Ruiz, y Alejandro Alvarez-Hernandez. Diastereoselective synthesis of spiro-beta-lactams via staudinger reaction. Heterocycles 71, 531-542 (2007). DOI: 10.3987/COM-06-10942


Abstract


In this work, eleven new spiro-?-lactams have been prepared using the Staudinger reaction of isomaleimides (1a-d) and carboxylic acids (chloroacetic acid, (-)-menthoxyacetic acid (7) and an oxazolidinone derived acid (10)) in the presence of triphosgene under mild condition. All reactions have been shown to be stereoselective. The new stereogenic centers were assigned by X-ray diffraction.



Producto de Investigación




Artículos relacionados

Highly diastereoselective alkylation, acylation and aldol condensation of cis- and trans-(N-acyloyl)...

Phenylboronic acid catalyzed-cyanide promoted, one-pot synthesis of 2-(2-hydroxyphenyl)benzoxazole d...

Diastereoselective Synthesis of Spiro-?-lactams via Staudinger Reactio

Aroylthioureas: new organic ionophores for heavy-metal ion selective electrodes

Stereoselective addition of allylmagnesium chloride to the CN bond of [4.3.0] boron heterobicycles

Synthesis of nitrogen-, oxygen- and sulphur-containing tripodal ligands with a trimethylbenzene core...

Cathepsins X and B Can Be Differentiated through Their Respective Mono- and Dipeptidyl Carboxypeptid...

Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of Pla...

Enantioselective synthesis of ?-amino acids. Part 10: Preparation of novel ?,?- and ?,?-disubstitute...

Synthesis of nitrogen-, oxygen- and sulphur-containing tripodal ligands with a trimethylbenzene core...