Determination of oxytetracycline in milk samples by polymer inclusion membraneseparation coupled to high performance liquid chromatography.Irma Pérez-Silva, José A. Rodríguez, Ma. Teresa Ramírez-Silva, Ma. Elena Páez-Hernández.Analytica Chimica Acta, 718, 2012, 42?46.DOI:10.1016/j.aca.2011.12.057
The determination of oxytetracycline in milk samples using a polymer inclusion membrane concept with high performance liquid chromatography (HPLC) was studied. The membranes developed are composed by cellulose acetate as polymer base, Cyanex 923 as carrier and o-nitrophenyl octyl ether as plasticizer. In the optimal conditions, the method exhibits good linearity in the range 0.03?0.20 mg L?1 with a limit of detection and quantification of 8.2 and 27.3 ?g L?1 respectively. The method was successfully applied to the analysis of milk samples with high selectivity.