Producción Científica Profesorado

Analysis of the electrochemical reactivity of natural hemozoin and ß-hemozoin in the presence of antimalarial drug

Veloz Rodríguez, María Aurora


Víctor Esteban Reyes-Cruz, Gustavo Urbano Reyes, María Aurora Veloz Rodríguez and José Luis Imbert Palafox. ?Analysis of the electrochemical reactivity of natural hemozoin and ?-hemozoin in the presence of antimalarial drug?. Electrochimica Acta, DOI: 10.1016/j.electacta 2011.08.029. Volumen 56, Issue, 30 November 2011, pages 9762-9768


We report an evaluation of the reactivity of hemozoin (HZ) and ?-hemozoin (?-HZ) obtained from the Triatoma Meccus longipennis, alone and in combination with quinine and amodiaquine. Using cyclic voltammetry and carbon paste electrodes, the redox processes that these compounds undergo were analysed. The results indicated that the atom Fe presence, the substance concentration, the drugs existence and the nature of the electrolytic medium are important in the redox processes. The strongest reactivity was for ?-HZ from Triatoma, which suggests that cellular molecules are embedded in an oxidising environment due to the presence of ?-HZ and indicates that like HZ, ?-HZ could be associate with phospholipid bilayers and interfere with their physical and chemical integrity, contributing to membrane breakdown and hyper-oxidation of molecules. It was further observed that when measuring the reactivity of HZ and ?-HZ with quinine and amodiaquine, a more oxidative stress was generated between the second one and the ?-HZ, which could explain the effectiveness of amodiaquine as a better antimalarial drug. Finally, it was concluded that electrochemical evaluation may be a convenient tool in determining the efficiency of antimalarial drugs and the identification of their redox processes.

Producto de Investigación

Artículos relacionados

Analysis of the electrochemical reactivity of natural hemozoin and ?-hemozoin in the presence of ant...

Evaluación de un derivado piridínico como inhibidor de corrosión en medio ácido

Recuperación de Ag sobre Acero Inoxidable en un Reactor electroquímico Tipo Prensa

Microwave-assisted synthesis of 2-(2-pyridyl)azoles. Study of their corrosion inhibiting properties

Electrorecuperación de Ag+ sobre Ti en un reactor electroquímico filtro prensa (ER01-FP)

Evaluación de la resistencia a la corrosión de aceros Pulvimetalurgicos inoxidables austéniticos sin...

Effect of Some Pyridine Derivatives on the Corrosion Behavior of Carbon Steel in an Environment Like...

Caracterización electroquímica de membranas líquidas soportadas para la extracción de Gd (III)

Estudio electroquímico del comportamiento de la reactividad de la pirita en un mineral de arsenopiri...

Electrorecuperación de Ag proveniente de efluentes radiográficos sobre A304 a diferentes potenciales...