Producción Científica Profesorado

Analysis of the electrochemical reactivity of natural hemozoin and ß-hemozoin in the presence of antimalarial drug



Veloz Rodríguez, María Aurora

2011

Víctor Esteban Reyes-Cruz, Gustavo Urbano Reyes, María Aurora Veloz Rodríguez and José Luis Imbert Palafox. ?Analysis of the electrochemical reactivity of natural hemozoin and ?-hemozoin in the presence of antimalarial drug?. Electrochimica Acta, DOI: 10.1016/j.electacta 2011.08.029. Volumen 56, Issue, 30 November 2011, pages 9762-9768


Abstract


We report an evaluation of the reactivity of hemozoin (HZ) and ?-hemozoin (?-HZ) obtained from the Triatoma Meccus longipennis, alone and in combination with quinine and amodiaquine. Using cyclic voltammetry and carbon paste electrodes, the redox processes that these compounds undergo were analysed. The results indicated that the atom Fe presence, the substance concentration, the drugs existence and the nature of the electrolytic medium are important in the redox processes. The strongest reactivity was for ?-HZ from Triatoma, which suggests that cellular molecules are embedded in an oxidising environment due to the presence of ?-HZ and indicates that like HZ, ?-HZ could be associate with phospholipid bilayers and interfere with their physical and chemical integrity, contributing to membrane breakdown and hyper-oxidation of molecules. It was further observed that when measuring the reactivity of HZ and ?-HZ with quinine and amodiaquine, a more oxidative stress was generated between the second one and the ?-HZ, which could explain the effectiveness of amodiaquine as a better antimalarial drug. Finally, it was concluded that electrochemical evaluation may be a convenient tool in determining the efficiency of antimalarial drugs and the identification of their redox processes.



Producto de Investigación




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