Producción Científica Profesorado

Cuprous oxide on charcoal-catalyzed ligand-free synthesis of 1,4-disubstituted 1,2,3-triazoles via click chemistry



Rojas Lima, Susana

2013

Heraclio López-Ruiz,* José Emilio de la Cerda-Pedro, Susana Rojas-Lima,* Imelda Pérez-Pérez, Brianda Viridiana Rodríguez-Sánchez, Rosa Santillan, and Oscar Coreño. Cuprous oxide on charcoal-catalyzed ligand-free synthesis of 1,4-disubstituted 1,2,3-triazoles via click chemistry. ARKIVOC, (iii) 139-164, (2013).


Abstract


Cuprous oxide on charcoal (Cu2O/C), the preparation of which is described for the first time, catalyzes the formation of 1,4-disubstituted 1,2,3-triazoles from organic azides and terminal alkynes in good to excellent yields (69-94%). These disubstituted triazoles can be equally efficiently generated in a one-pot process from alkyl bromides, sodium azide, and terminal acetylenes in 50% aqueous isopropanol containing a suspension of the catalyst. This obviates the necessity to isolate potentially explosive organic azides.



Producto de Investigación




Artículos relacionados

Enantioselective synthesis of ?-amino acids. Part 10: Preparation of novel ?,?- and ?,?-disubstitute...

Et3, and efficient Mediator for Xanthate Transfer Based Radical Processes.

Preparation of Seven- and Eight-Membered Boron Heterocycles from Different Salen Ligands and Arylbor...

Structure-Activity Relationships for Inhibition of Cysteine Protease Activity and Development of Pla...

Phenylboronic acid catalyzed-cyanide promoted, one-pot synthesis of 2-(2-hydroxyphenyl)benzoxazole d...

Diastereoselective alkylation of chiral glycinate derivatives containing the ?-phenylethyl group.

Furocoumarins of three species of the genus Dorstenia

Addition reaction of benzylbenzylidenenamine to lithium enolates of 1,3-dioxolan-4-one: synthesis of...

Aroylthioureas: new organic ionophores for heavy-metal ion selective electrodes

Addition reaction of benzylbenzylidenenamine to lithium enolates of1,3-dioxolan-4-one: synthesis of ...