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Ellagitannins from Geranium potentillaefolium and G. bellum

Gayosso De Lucio, Juan Antonio


2010. Ellagitannins from Geranium potentillaefolium and G. bellum


The aerial parts of Geranium potentillaefoium afforded geraniin (1), corilagin (2), gallic acid (4), methyl gallate (6), methylbrevifolincarboxylate (7), quercetin, quercetin 3-O-?-D-glucopyranoside, quercetin 3-O-?-D-[6?-O-galloyl)glucopyranoside,kaempferol, ?-sitosterol 3-O-?-D-glucopyranoside and ?-sitosterol, while the aerial parts of G. bellum gave the samecompounds in addition to kaempferol 3-O-?-D-glucopyranoside, isolated instead of kaempferol. The substances were identifiedby 1D and 2D NMR spectroscopy in comparison with published data. The water decoction preparations from air-dried plantmaterials (2.5 g) contain ca. 4.6 % of the ellagitannin 1, envisaging that when such decoction is ingested (250 mL), atherapeutic dose of ca. 36 mg of the antitumor ellagic acid (3) may be incorporated into the organism.Keywords: Geranium potentillaefolium, Geranium bellum, chemical composition, ellagitannins, antitumor compounds

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