Producción Científica Profesorado

Diastereoselective Synthesis of Spiro-?-lactams via Staudinger Reactio



Lopez Ruíz, Heraclio

2007

Susana Rojas-Lima, Lidia Santillan-Sid, Heraclio López-Ruiz, y Alejandro Alvarez-Hernandez. Diastereoselective synthesis of spiro-beta-lactams via staudinger reaction. Heterocycles 71, 531-542 (2007). DOI: 10.3987/COM-06-10942


Abstract


In this work, eleven new spiro-?-lactams have been prepared using the Staudinger reaction of isomaleimides (1a-d) and carboxylic acids (chloroacetic acid, (-)-menthoxyacetic acid (7) and an oxazolidinone derived acid (10)) in the presence of triphosgene under mild condition. All reactions have been shown to be stereoselective. The new stereogenic centers were assigned by X-ray diffraction.



Producto de Investigación




Artículos relacionados

r-Alkylation of (S)-Asparagine with Self-Regeneration of the Stereogenic Center: Enantioselective Sy...

Further insight into three center hydrogen bonding. Participation in tautomeric equilibria of hetero...

Synthesis and Structures of some Lithium and Sodium (Aminoalcoholato)hydrido Aluminates

X-ray crystallographic study of neutral boron chelates with ?-diketones and tropolone

Diastereoselective Synthesis of Spiro-?-lactams via Staudinger Reactio

Furocoumarins of three species of the genus Dorstenia

Synthesis of nitrogen-, oxygen- and sulphur-containing tripodal ligands with a trimethylbenzene core...

Et3B, an Efficient Mediator for Xanthate Transfer Based Radical Processes

O-benzyl-N-(2-furoyl)thiocarbamate

Phenylboronic acid catalyzed-cyanide promoted, one-pot synthesis of 2-(2-hydroxyphenyl)benzoxazole d...