Producción Científica Profesorado

The Combination of Naproxen and Citral Reduces Nociception and Gastric Damage in Rats

Cariño Cortés, Raquel


Ortiz MI, Ramírez-Montiel ML, González-García MP, Ponce-Monter HA, Castañeda-Hernández G, Cariño-Cortés R.The combination of naproxen and citral reduces nociception and gastric damage in rats.Arch Pharm Res. 2010 Oct;33(10):1691-7. ISSN 0253-6269


It has been shown that the association of non-steroidal anti-inflammatory drugs with plantextracts can increase their antinociceptive activity, allowing the use of lower doses and, thus,limiting side effects. Therefore, the aim of this study was to examine the effects of the interactionbetween naproxen and citral on nociception and gastric injury in rats. Naproxen, citral,or combinations of naproxen and citral produced an antinociceptive effect. The administrationof naproxen produced significant gastric damage, but this effect was not obtained with eithercitral or the naproxen-citral combination. The ED50 value was estimated for the individualdrugs and an isobologram was constructed. The derived theoretical ED50 for the antinociceptiveeffect (423.8 mg/kg) was not significantly different from the observed experimental value(359.0 mg/kg); hence, the interaction between naproxen and citral mediating the antinociceptiveeffect is additive. These data suggest that the naproxen-citral combination interacts atthe systemic level, produces minor gastric damage, and potentially has therapeutic advantagesfor the clinical treatment of inflammatory pain.

Producto de Investigación UAEH

Artículos relacionados

Exposure to Sodium Fluoride Produces Signs of Apoptosis in Rat Leukocytes

Fluorides and dental fluorosis in students from Tula de Allende Hidalgo, Mexico

Effect of Sodium Fluoride Ingestion on Malondialdehyde Concentration and the Activity of Antioxidant...

Antigenotoxic Studies of Different Substances to Reduce the DNA Damage Induced by Aflatoxin B1 and O...

Effect of Naringin on the DNA Damage Induced by Daunorubicin in Mouse Hepatocytes and Cardiocytes

Antigenotoxic Effect of Chamomilla recutita (L.) Rauschert Essential Oil in Mouse Spermatogonial Cel...

Lead, Cadmium and Cobalt (Pb, Cd, and Co) Leaching of Glass-Clay Containers by pH Effect of Food

In vivo extracellular matrix protein expression by human periodontal ligament after stimulation with...

Inflammation, Oxidative Stress, and Obesity

Antigenotoxic Studies of Different Substances to Reduce the DNA damage Induced by Aflatoxin B1 and ...